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Saritha is a South Indian actress. She has acted more than 140 films in Tamil, Telugu, Kannada and Malayalam languages. and has also acted in a television serial Selvi in 2005. Her mainstream career spanned from 1978 to 1989, when she took a break to marry Indian actor and producer Mukesh and raise their two sons.

Saritha made her acting debut through Maro Charithra, a Telugu film directed by K. Balachander. The movie dealt with Cross-cultural romance, where she acted opposite Kamal Haasan as a Telugu speaking girl. She received more offers in Tamil films mostly directed by Balachander. Some of her films include Thappu Thalangal, Idi Katha Kaadu, Vandichakkaram, Netrikan, Agni Sakshi and Puthukavithai, Kalyana Agathigal and Achamillai Achamillai. Her performance in Vandichakkaram (1980) and Achamillai Achamillai (1984) won her Filmfare Best Tamil Actress awards. She also played guest roles as herself in 47 Natkal and its Telugu remake, directed by Balachander.

She had her head tonsured for the cancer-affected girl role in Sujatha in 1980 and gained several pounds to play the psychotic role in the 2005 film Julie Ganapathi. Neither of these films were successful. She also won a Nandi Special Jury Award for her performance as "Aandaalu" in the movie Arjun in 2004.

Saritha has also worked as a Voice actor in Telugu and Tamil films. She has lent her voice to various other actresses including Soundarya, Ramya Krishnan, Nagma and Vijayashanti. She won Nandi Award for Best Female Dubbing Artist for her voice to Soundarya in Maa Ayana Bangaram (1997) and Anthapuram (1999).